摩尔多瓦所在地区是地球上最古老的葡萄种植区之一，这里曾经种植有各种野生葡萄，现代摩尔多瓦酿酒师的祖先就是用这些野生葡萄酿酒的。
摩尔多瓦北部有一个Naslavcia村，从该村附近的葡萄树化石研究得出，葡萄种植从大约6百万到2500万年前就已经在这里开始了。
公元前2800年，在Varvarovca村附近发现的葡萄籽证明了当时的葡萄栽培。
后发展到四五千年前，在德涅斯特河和普鲁特河流域，人们就已经开始种植葡萄并进行葡萄酒酿造。
虽然中间时有起伏，但是随着经济和社会条件的变化，该区域葡萄种值与葡萄酒的酿造已经基本稳定下来了。
公元前七世纪时，当地居民就已经用自己种植的葡萄与生活在亚速和黑海地区的希腊殖民者进行交易。
自那时起，摩尔多瓦的葡萄酒已经找到了自己的追随者，并在众多酒庄中赢得一席之地。

The territory on which the current Moldova is located is one of the oldest wine-growing regions of the planet. Once upon a time, wild grapes grew in abundance here, from which the ancestors of modern Moldovan winemakers made drinks. Fossils of Vitis teutonica vine leaves near the Naslavcia village in the north of Moldova indicate that grapes grew here approximately 6 to 25 million years ago. The size of grape seed imprints found near the Varvarovca village, which date back to 2800 BC, prove that at that time the grapes were already being cultivated.
The grapegrowing and wine-making in the area between the Nistru and Prut rivers, which began 4000–5000 years ago, had periods of rises and falls but has survived through all the changing social and economic conditions. In the VII century BC. local residents began to cultivate the vine and trade with Greek colonists living in the territories along the Azov and Black Seas. Since then, the wines of Moldova have found their fans and won a place on the tables of many admirers of the talent of Moldovan winemakers.

十四世纪摩尔多瓦封建王国形成以后，在十五世纪，葡萄种植就开始蓬勃发展， 当时正值斯蒂芬大帝统治时期，他提倡引进优良品种，提高葡萄酒的质量，因此成为中世纪时期摩尔多瓦主要出口物品之一。

After the formation of the Moldavian feudal state in the 14th century, grape-growing began to develop and flourished in the 15th century during the kingdom of Stephen the Great, who promoted the import of high quality varieties and the improvement of the quality of wine, which was one of the chief exports of Moldova throughout the medieval period.

1812年“布加勒斯特条约”之后，该地区成为俄罗斯帝国的省份，自此葡萄酒业再次得以兴盛。
主要酿造传统型的：RarăNeagră，Plavai，Galbena，Zghiharda，BatutaNeagră，FeteascăAlbă，FeteascăNeagră，Tămâioasa，Cabasia。 此外，还有许多来自匈牙利、保加利亚、希腊和土耳其等的品种。葡萄种植者在当时获得政府的大力支持，1837年，比萨拉比亚的葡萄园面积已达14000公顷，葡萄酒产量高达1200万升。 19世纪下半叶，开始大规模引进法国新品种，如Cabernet Sauvignon，Merlot，Pinot blanc，Pinot noir，Pinot gris，Aligote，Sauvignon blanc，Gamay，Muscat blanc等。 正是在这个时候，摩尔多瓦成为著名的葡萄酒生产基地，Negru de Purcari和Romanesti等品种也开始在此地进行酿造。

After the Treaty of Bucharest in 1812, when the region became a province of the Russian Empire, the wine industry flourished again. The main varieties were the traditional ones: Rară Neagră, Plavai, Galbena, Zghiharda, Batuta Neagră, Fetească Albă, Fetească Neagră, Tămâioasa, Cabasia and many other local, Hungarian, Bulgarian, Greek, and Turkish varieties. In this period, the grape growers gained governmental support and by 1837 the vineyard area in Bessarabia reached 14,000 hectares, and the wine production reached 12 million litres. The second half of the 19th century saw an intensive planting of newly introduced French varieties, such as Cabernet Sauvignon, Merlot, Pinot blanc,Pinot noir, Pinot gris, Aligote, Sauvignon blanc, Gamay, Muscat blanc. It was at this time that wines like Negru de Purcari and Romanesti, which have made Moldova famous as a fine wine producer, began to be produced.

两次世界大战摧毁了摩尔多瓦的葡萄酒产业。 20世纪50年代的苏维埃时期，摩尔多瓦葡萄园才开始重新建立，十多年来种植了十五万公顷葡萄，至1960年，葡萄园总面积已达22万公顷。

Both World Wars damaged the Moldolvan vineyards and the wine industry considerably. The re-establishment of Moldavian vineyards began during Soviet years, in the 1950s. Over 150,000 hectares were planted in 10 years, and by 1960 the total vineyard area had reached 220,000 hectares.